Practice Question
A patient who experiences gout has a serum urate level of 5 mg/dL and inadequate urate excretion. Which medication indicated in the treatment of gout is the best choice to improve the excretion of urate for this patient?
Answer Choices:
Correct Answer:
Probenecid (Benemid)
Rationale:
🟦 Probenecid is a uricosuric agent that specifically increases renal excretion of uric acid.
🟦 It works by inhibiting urate reabsorption in the renal tubules, lowering serum urate levels.
🟦 This medication is most effective in clients with inadequate urate excretion, as described in the scenario.
🟦 A serum urate level of 5 mg/dL with poor excretion indicates a need to enhance uric acid elimination, not reduce production.
🟦 Therefore, probenecid directly addresses the underlying pathophysiology in this patient.
Colchicine
🟦 Colchicine reduces inflammation during acute gout attacks.
🟦 It does not affect uric acid excretion or production.
Indomethacin (Indocin)
🟦 Indomethacin is an NSAID used for pain and inflammation in acute gout.
🟦 It does not alter urate levels.
Allopurinol (Zyloprim)
🟦 Allopurinol decreases uric acid production by inhibiting xanthine oxidase.
🟦 It is preferred for overproduction, not inadequate excretion.
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This question is from Pharmacology Exam Final which contains 85 questions.
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Question Details
- Category: RN Nursing Exam(s)
- Subcategory: General Exams
- Domain: 🚑Pharmacology
- Answer Choices: 4