Practice Question
A patient has bacterial endocarditis, and a culture reveals Gram-positive streptococcus. Which antibiotic should the nurse expect to administer because it is a protein-synthesis inhibitor
Answer Choices:
Correct Answer:
Clindamycin (Cleocin)
Rationale:
🟦 Clindamycin is a protein-synthesis inhibitor that works by binding to the 50S ribosomal subunit of bacteria.
🟦 This action prevents peptide chain elongation, effectively stopping bacterial growth.
🟦 Clindamycin is effective against Gram-positive organisms, including streptococci, which are common causes of bacterial endocarditis.
🟦 It is especially useful in clients who have penicillin allergies.
🟦 Because the question specifically asks for a protein-synthesis inhibitor, clindamycin is the correct choice.
Amikacin (Amikin)
🟦 Aminoglycoside with ribosomal binding but not primary for streptococcal endocarditis.
🟦 It is mainly used for Gram-negative infections and carries a high risk of nephrotoxicity.
Tobramycin (Nebcin)
🟦 Primarily targets Gram-negative organisms, not streptococcus.
🟦 It is not typically used as the main agent for Gram-positive endocarditis.
Gentamicin (Garamycin)
🟦 Used as synergistic therapy, not as a primary protein-synthesis inhibitor for streptococcus.
🟦 It is often combined with beta-lactams rather than used alone.
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This question is from Pharmacology Exam Final which contains 85 questions.
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Question Details
- Category: RN Nursing Exam(s)
- Subcategory: General Exams
- Domain: 🚑Pharmacology
- Answer Choices: 4