Practice Question
A client newly prescribed phenelzine (Nardil) for treatment-resistant depression expresses interest in incorporating more fermented foods into their diet. Based on the pharmacodynamics of this medication, which dietary counseling statement best demonstrates the nurse's advanced understanding of safety implications?
Answer Choices:
Correct Answer:
"Unregulated intake of fermented and aged products can precipitate a hypertensive crisis due to tyramine accumulation."
Rationale:
🔴 Phenelzine (Nardil) is a monoamine oxidase inhibitor (MAOI) used for treatment-resistant depression. MAOIs block the enzyme monoamine oxidase, which normally breaks down tyramine, a substance found in fermented, aged, or pickled foods (e.g., aged cheese, cured meats, soy products, fermented vegetables).
🔴 When tyramine builds up due to MAO inhibition, it can cause a sudden and severe hypertensive crisis by promoting excessive release of norepinephrine, a life-threatening event.
🔴 Clients on MAOIs must be counseled to avoid high-tyramine foods, especially fermented products, unless otherwise approved by a provider.
🔴 The other statements are inaccurate: fermented foods do not enhance MAO activity , do not reduce side effects through antioxidants , and cannot be safely consumed just by adjusting hydration or sodium levels .
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This question is from Examplify 1 which contains 49 questions.
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Question Details
- Category: RN Nursing Exam(s)
- Subcategory: Examplify Exam(s)
- Domain: Pharmacology
- Answer Choices: 4