Practice Question
A patient with acute gout asks you why allopurinol cannot be used at this time. What is your best response?
Answer Choices:
Correct Answer:
"Allopurinol is used only for the prevention of gout attacks."
Rationale:
💊Allopurinol lowers serum uric acid by inhibiting xanthine oxidase, making it a prophylactic agent to prevent future flares rather than treat an acute gout attack.
💊During an acute flare, pain and inflammation are best managed with NSAIDs, colchicine, or corticosteroids, not urate-lowering therapy initiation.
💊Starting or adjusting allopurinol during a flare can destabilize urate pools and is associated with worsening/prolongation of acute symptoms.
💊Allopurinol is typically initiated after the acute episode resolves, often with anti-inflammatory prophylaxis (e.g., low-dose colchicine) to prevent flare precipitation.
💊Key teaching is that allopurinol provides long-term control of hyperuricemia and reduces tophi formation, but it does not relieve acute pain.
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This question is from Custom FRIEDMAN-PHARM-CH 12-13-15 (Pain-Inflam-Immune) (1) which contains 52 questions.
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From Exam
Custom FRIEDMAN-PHARM-CH 12-13-15 (Pain-Inflam-Immune) (1)
52 Questions
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- Category: LPN Nursing Exam(s)
- Subcategory: LPN ATI Exams
- Domain: Pharmacology
- Answer Choices: 4