Practice Question
A patient who experiences gout has a serum urate level of 5 mg/dL and inadequate urate excretion. Which medication indicated in the treatment of gout is the best choice to improve the excretion of urate for this patient?
Answer Choices:
Correct Answer:
Probenecid (Benemid)
Rationale:
💎 Probenecid is a uricosuric medication that increases renal elimination of uric acid
💎 The patient’s gout is caused by inadequate urate excretion, not excess uric acid production
💎 Probenecid works at the proximal renal tubule, where uric acid is normally reabsorbed
💎 It inhibits urate reabsorption, allowing more uric acid to remain in the urine
💎 Increased urinary excretion leads to lower serum urate levels over time
💎 This mechanism directly corrects the under-excretion pathophysiology of gout
💎 Because it targets the root cause, probenecid is the most appropriate long-term therapy
❌ Incorrect Options
❌ Colchicine
❌ Colchicine suppresses inflammatory response by inhibiting neutrophil activity
❌ It does not lower uric acid levels or improve urate excretion
❌ Indomethacin (Indocin)
❌ Indomethacin is an NSAID used for pain and inflammation during acute gout attacks
❌ It does not influence uric acid synthesis or elimination
❌Allopurinol (Zyloprim)
❌ Allopurinol decreases uric acid production by inhibiting xanthine oxidase
❌ It is more appropriate for overproduction, not under-excretion of urate
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☑️ Pharmacology Exam-Miami Regional University
84 Questions
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- Category: RN Nursing Exam(s)
- Subcategory: General Exams
- Domain: 🚑Pharmacology
- Answer Choices: 4