Practice Question
A patient is ordered simvastatin. Which data in the patient history is most concerning?
Answer Choices:
Correct Answer:
A history of hepatitis B
Rationale:
♦️Simvastatin is metabolized extensively in the liver, and preexisting liver disease (e.g., hepatitis B) increases the risk of hepatotoxicity.
♦️Statins can elevate serum transaminases (AST, ALT) and, in some cases, cause liver failure if used in patients with compromised hepatic function.
♦️Before starting therapy, baseline liver function tests (LFTs) must be obtained and closely monitored throughout treatment.
♦️Patients should be instructed to report jaundice, dark urine, right upper quadrant pain, or fatigue, as these may indicate liver injury.
♦️This history is the most concerning because hepatic impairment impairs drug metabolism, leading to potential drug accumulation and toxicity.
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This question is from Examplify Pharmacology Exam 2 Fall 2025 Section 02 which contains 60 questions.
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From Exam
Examplify Pharmacology Exam 2 Fall 2025 Section 02
60 Questions
View Full Exam Start PracticingQuestion Details
- Category: RN Nursing Exam(s)
- Subcategory: Examplify Exam(s)
- Domain: Pharmacology
- Answer Choices: 4