Practice Question
Which of the following medications is contraindicated in a patient with medullary thyroid cancer?
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Correct Answer:
Glucagon-like peptide-1 (GLP-1) agonists
Rationale:
⚠️ GLP-1 agonists (e.g., exenatide, liraglutide) have a black box warning for potential risk of medullary thyroid carcinoma (MTC) based on rodent studies showing increased incidence of C-cell tumors.
⚠️ Although the risk in humans is not definitively established, GLP-1 agonists are contraindicated in patients with a personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
⚠️ Other diabetes medications such as sulfonylureas, SGLT2 inhibitors, and TZDs do not carry specific contraindications related to medullary thyroid cancer.
⚠️ Prescribers must assess patient history thoroughly to avoid exacerbating underlying cancer risks.
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This question is from Examplify 2 which contains 135 questions.
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Question Details
- Category: RN Nursing Exam(s)
- Subcategory: Examplify Exam(s)
- Domain: Pharmacology
- Answer Choices: 4