Practice Question
Which difference in pharmacokinetics does the nurse expect in the obese patient as compared with the thin patient with administration of a highly lipid-soluble drug?.
Answer Choices:
Correct Answer:
Drug elimination will be slowed.
Rationale:
🟢 Highly lipid-soluble drugs accumulate extensively in adipose tissue, which is more abundant in obese patients.
🟢 This accumulation creates a drug reservoir, allowing the medication to slowly leach back into circulation over time.
🟢 As a result, the half-life of the drug is prolonged, and it takes longer for the drug to be cleared from the body.
🟢 The primary pharmacokinetic change in obesity with lipid-soluble drugs is slowed elimination, not absorption or metabolism.
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This question is from ATI PN Custom Pharmacology which contains 40 questions.
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Question Details
- Category: LPN Nursing Exam(s)
- Subcategory: LPN ATI Exams
- Domain: Pharmacology
- Answer Choices: 4