🟦 Primary immunodeficiency is caused by inherited/genetic defects that result in missing or malfunctioning immune components (e.g., B cells, T cells, phagocytes, complement).

🟦 When there is loss or dysfunction of these components, the body cannot mount an effective defense against pathogens.

🟦 This leads to recurrent, severe, or unusual infections, often beginning in infancy or childhood.

🟦 The key pathophysiology is an insufficient immune response because a necessary part of the immune system is absent or defective.

🟦 Examples include disorders like SCID or Bruton agammaglobulinemia, where specific immune functions are profoundly reduced.

Excessive immune response to an antigen

🟦This describes an overactive immune reaction, which is more consistent with hypersensitivity or allergy.

🟦It does not indicate a deficient or missing immune function.

Unable to distinguish self from non-self antigens

🟦This reflects autoimmune disease, where the immune system attacks the body’s own tissues.

🟦It is not the core mechanism of primary immunodeficiency.

Hypersensitivity reaction to an antigen

🟦Hypersensitivity involves an exaggerated immune response (e.g., allergy, anaphylaxis).

🟦It is the opposite of immune deficiency.

🟩 Regeneration is healing in which damaged cells are replaced by the same type of cells, restoring normal tissue structure and function.

🟩 Because the original tissue is rebuilt, there is little to no scar formation.

🟩 This occurs best in tissues with strong regenerative capacity (e.g., epidermis, some liver tissue).

🟩 The hallmark is minimal tissue loss and the tissue returns close to its pre-injury state.

🟩 Clinically, regeneration means rapid recovery with near-normal appearance and function.

Replacement

🟩 Replacement often implies the tissue is filled in with different tissue (commonly fibrous tissue) rather than original cells.

🟩 That process commonly results in scarring.

Scar formation

🟩Scar formation occurs when healing requires collagen deposition due to deeper injury or tissue loss.

🟩 It typically leaves permanent scar tissue.

Resolution

🟩Resolution usually refers to the end of inflammation with return toward normal, especially in infections/inflammatory processes.

🟩 It is not the standard term for complete wound healing without scarring like regeneration.

🟨 A pressure injury breaks the skin barrier, creating an entry point for bacteria, which can lead to cellulitis.

🟨 Cellulitis is a spreading bacterial infection of the skin and subcutaneous tissues characterized by warmth, redness, swelling, and pain.

🟨 Pressure injuries can worsen quickly because impaired tissue perfusion reduces oxygen delivery and weakens local defense mechanisms.

🟨 Infection risk increases with deeper ulcers, necrotic tissue, and moisture, making skin infection a common complication.

🟨 Untreated cellulitis may progress to osteomyelitis or sepsis, so early detection is critical.

Osteoarthritis

🟨Osteoarthritis is a degenerative joint disease related to cartilage breakdown, not skin breakdown.

🟨 It is not caused by pressure injuries.

Anemia

🟨Anemia is not a direct typical complication of a pressure injury, though severe chronic wounds can contribute to systemic issues in some cases.

🟨The most immediate complication is usually infection.

Diabetes

🟨Diabetes is a risk factor for poor wound healing, not a complication caused by pressure ulcers.

🟨Pressure injuries do not create diabetes.

Increased sodium retention

🟦 Aldosterone acts on the distal nephron to increase sodium reabsorption by upregulating sodium channels and sodium-potassium pumps.

🟦 This leads to increased sodium retention, meaning more sodium stays in the bloodstream rather than being lost in urine.

🟦 Sodium is the major extracellular ion that strongly influences osmotic pressure, so retaining sodium helps pull water back into circulation.

🟦 This mechanism supports fluid balance during stress when the body is trying to maintain effective circulating volume.

🟦 The key takeaway is that aldosterone’s hallmark action is saving sodium to support volume and perfusion.

Increased blood pressure

🟦 When aldosterone causes sodium retention, it also promotes water retention because water follows sodium.

🟦 This increases intravascular volume, which raises venous return and supports cardiac output.

🟦 Increased circulating volume contributes directly to increased blood pressure, especially during physiologic stress.

🟦 This response helps preserve perfusion to vital organs (brain, heart, kidneys) when the body is under threat.

🟦 Clinically, this is why aldosterone excess can worsen hypertension and fluid overload in susceptible clients.

Decreased inflammatory response

🟦 Decreased inflammation is primarily driven by cortisol (glucocorticoids), which suppress inflammatory mediators.

🟦 Aldosterone’s main function is electrolyte and fluid regulation, not inflammation control.

Decreased wound healing

🟦 Poor wound healing is commonly linked to cortisol because it increases protein breakdown and reduces collagen formation.

🟦 Aldosterone does not directly suppress tissue repair as its primary action.

Decreased antibody production

🟦 Reduced antibody production reflects immune suppression, most associated with cortisol and stress-related glucocorticoid effects.

🟦 Aldosterone does not primarily regulate antibody synthesis.

🟣 Scar tissue forms when the body repairs injury with dense collagen rather than restoring original tissue architecture.

🟣 Collagen fibers are strong but less flexible, so the repaired area becomes stiffer than normal tissue.

🟣 This causes reduced elasticity, meaning the tissue does not stretch and recoil normally.

🟣 The loss of elasticity can limit movement and may contribute to contractures, especially over joints.

🟣 Scarred areas also lack many normal skin structures, reinforcing reduced functional compliance.

Excessive metabolic activity

🟣 Metabolic activity is higher during early healing phases, not in mature scar tissue.

🟣 A healed scar becomes relatively stable and does not remain hypermetabolic.

Regeneration of specialized cells

🟣 Scar tissue indicates fibrosis, not true regeneration of specialized cells.

🟣 Regeneration restores original cell type with minimal scarring, which is not the case here.

Improved sensory perception

🟣 Sensation is often reduced or altered because nerve endings may be disrupted.

🟣 Improved sensory perception is not a typical outcome of scar formation.

🔷 Basophils are granulocytes involved in allergic and inflammatory immune responses.

🔷 They have surface receptors that bind IgE, which becomes activated when an allergen cross-links the IgE.

🔷 Activation triggers release of histamine and other mediators that cause vasodilation and increased capillary permeability.

🔷 These changes contribute to airway swelling, bronchospasm, and shock features seen in anaphylaxis.

🔷 This makes basophils key cells in IgE-mediated immediate hypersensitivity reactions.

Become macrophages

🔷Monocytes migrate into tissues and become macrophages, not basophils.

🔷Basophils remain granulocytes and do not differentiate into macrophages.

Become B-memory cells

🔷B lymphocytes create memory cells and antibodies in humoral immunity.

🔷Basophils do not function as B cells and do not form immune memory.

Used for phagocytosis

🔷Neutrophils and macrophages are primary phagocytes in nonspecific defense.

🔷Basophils mainly release chemical mediators rather than engulf pathogens.

🟢 Primary intention healing occurs when wound edges are approximated and secured with sutures, staples, or adhesive strips.

🟢 Because the edges meet, there is minimal tissue loss and less need for granulation tissue to fill the defect.

🟢 Healing occurs faster with a smaller inflammatory response and reduced risk of large scar formation.

🟢 The resulting scar is typically thin and linear, especially with proper wound care and infection prevention.

🟢 Surgical incisions are the classic example of wounds healing by primary intention.

Tertiary intention

🟢Tertiary (delayed primary closure) leaves the wound open initially due to contamination risk and closes it later.

🟢It is not immediate edge closure from the start.

Quaternary intention

🟢This is not a standard wound healing intention classification used in core nursing wound care.

🟢The recognized categories are primary, secondary, and tertiary intention.

Secondary intention

🟢Secondary intention occurs when edges cannot be approximated and the wound heals by granulation and contraction.

🟢This takes longer and often results in more scarring.

🔴 Anaphylaxis is a severe systemic reaction that can rapidly lead to shock.

🔴 Massive mediator release (especially histamine) causes widespread vasodilation and capillary leakage.

🔴 This lowers circulating volume and vascular tone, producing hypotension, a key sign of anaphylactic shock.

🔴 Hypotension indicates systemic compromise, which differentiates anaphylaxis from localized allergic findings.

🔴 It is an emergency requiring rapid treatment (e.g., epinephrine) to prevent airway and cardiovascular collapse.

Hives

🔴Hives can occur with mild allergy and reflect localized histamine response.

🔴Alone, they do not confirm life-threatening systemic involvement.

Red rash

🔴A red rash may be mild and localized without cardiovascular compromise.

🔴It is not as specific for anaphylaxis as hypotension.

Itching of the arms

🔴Itching can be a mild allergic symptom and is often limited to the skin.

🔴It does not indicate shock physiology.