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Hint : 🧪 CF diagnosis = high chloride in sweat

Correct Answers:

  • Sweat chloride test


Rationale :

🧪 The sweat chloride test is the gold standard diagnostic test for cystic fibrosis (CF).

🧪 It measures the concentration of chloride in the child's sweat, which is elevated due to a defect in the CFTR gene affecting chloride transport.

🧪 A chloride level >60 mEq/L on two separate tests is diagnostic for CF.

🧪 This test is noninvasive, reliable, and typically performed at specialized centers using pilocarpine iontophoresis to stimulate sweating.

🧪 While other tests (e.g., stool fat, sputum culture, or pulmonary function) support the diagnosis or monitor progression, they do not confirm CF alone.


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