End
1 :

Hint : 💊 Corticosteroids may require gradual withdrawal.

Correct Answers:

  • Do not stop this medication suddenly; you will have to taper dosage gradually.


Rationale :

✏️ Prednisone is a glucocorticoid that can suppress the body's normal hypothalamic-pituitary-adrenal (HPA) axis when systemic therapy is sufficient in dose and duration.

✏️ Abruptly discontinuing glucocorticoid therapy after clinically significant adrenal suppression can result in acute adrenal insufficiency.

✏️ Manifestations of adrenal insufficiency can include weakness, fatigue, hypotension, nausea, vomiting, hypoglycemia, and electrolyte abnormalities.

✏️ Gradually tapering the dose allows endogenous adrenal corticosteroid production to recover when tapering is clinically indicated.

✏️ The parent should administer prednisone exactly as prescribed and should not independently change or discontinue the medication.

✏️ Very brief corticosteroid courses do not always require tapering, so the prescribed regimen and healthcare provider's instructions should be followed.

✏️ Prednisone can also increase susceptibility to infection and may produce metabolic and gastrointestinal adverse effects during treatment.

✏️ Teaching caregivers not to abruptly discontinue systemic corticosteroids when a taper has been prescribed is therefore an important medication-safety instruction.


Distractor Analysis :

Rationale for Incorrect Options to be Available Soon

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