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Hemolytic transfusion reaction โ๏ธ Correct
๐ Why this is correct
๐น An acute hemolytic transfusion reaction (AHTR) is the most serious and life-threatening transfusion reaction and usually occurs because of ABO incompatibility, causing the recipient's antibodies to rapidly destroy transfused red blood cells.
๐น The reaction typically develops within the first 15โ30 minutes of starting the transfusion, exactly as seen in this client, whose symptoms began 15 minutes after the transfusion was initiated.
๐น The adolescent exhibits the classic manifestations of an acute hemolytic reaction:
๐ก๏ธ Fever (37.4ยฐC โ 38.1ยฐC)
โ๏ธ Chills
๐ค Headache
๐ฉธ Flank pain (a hallmark sign due to kidney involvement)
๐ Chest tightness
โค๏ธ Tachycardia (78 โ 104/min)
๐ฉธ Hypotension (100/60 โ 90/50 mm Hg)
๐น During hemolysis, transfused RBCs rupture, releasing free hemoglobin into the bloodstream, which can obstruct the renal tubules and lead to acute kidney injury.
๐น The client is also at risk for shock, disseminated intravascular coagulation (DIC), renal failure, and death if treatment is delayed.
๐น The nurse's immediate priorities include:
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Stop the transfusion immediately.
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Maintain IV access with normal saline using new tubing.
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Notify the provider and blood bank.
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Send the blood bag and tubing to the laboratory.
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Monitor for shock and renal failure.
๐น Rapid recognition and intervention are essential to prevent irreversible organ damage.
๐ Key Point: Fever, chills, flank pain, hypotension, and tachycardia shortly after starting a transfusion indicate an acute hemolytic transfusion reaction.
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Actions to Take
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Send donor blood back to the laboratory. โ๏ธ Correct
๐ Why this is correct
๐น After stopping the transfusion, the nurse should return the blood bag, attached tubing, and any remaining blood to the blood bank/laboratory.
๐น The laboratory will investigate for ABO incompatibility, bacterial contamination, clerical errors, or other causes of the reaction.
๐น The blood bank will compare the donor blood with the recipient's blood to determine the source of the incompatibility.
๐น Returning the blood product is essential for confirming the diagnosis and preventing similar errors in future transfusions.
๐น This is a standard nursing intervention whenever a serious transfusion reaction is suspected.
๐ Key Point: Always send the blood product and tubing back to the laboratory after a suspected hemolytic reaction.
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Insert an indwelling urinary catheter with urometer. โ๏ธ Correct
๐ Why this is correct
๐น Hemolysis releases free hemoglobin, which is filtered by the kidneys and can cause acute tubular necrosis and acute kidney injury.
๐น A urinary catheter with a urometer allows the nurse to accurately monitor hourly urine output, one of the best indicators of renal perfusion and kidney function.
๐น Monitoring urine output helps detect early signs of renal failure, allowing prompt intervention.
๐น The nurse should also assess the urine for hemoglobinuria, which commonly produces dark, red, or cola-colored urine.
๐น Maintaining adequate urine output is essential for preventing further renal damage.
๐ Key Point: Accurate urine monitoring helps detect kidney injury caused by hemoglobin released during hemolysis.
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Parameters to Monitor
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Manifestations of shock โ๏ธ Correct
๐ Why this is correct
๐น Acute hemolytic transfusion reactions can rapidly progress to circulatory collapse and shock.
๐น The nurse should monitor for:
โค๏ธ Persistent tachycardia
๐ฉธ Worsening hypotension
๐ก๏ธ Cool, clammy skin
๐ฐ Altered level of consciousness
๐ฎ Rapid respirations
๐ง Poor peripheral perfusion
๐น Early recognition of shock allows rapid treatment with IV fluids, medications, and supportive care.
๐ Key Point: Shock is a life-threatening complication of acute hemolytic transfusion reactions.
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Urine color โ๏ธ Correct
๐ Why this is correct
๐น During intravascular hemolysis, large amounts of free hemoglobin enter the bloodstream and are filtered into the urine.
๐น The urine may become red, brown, or cola-colored (hemoglobinuria), indicating significant destruction of transfused red blood cells.
๐น Monitoring urine color provides valuable information about the severity of hemolysis and the risk of kidney injury.
๐น Changes in urine color should be reported immediately because they may indicate worsening renal damage.
๐น The nurse should monitor both urine output and urine appearance throughout the client's recovery.
๐ Key Point: Dark or red urine is a classic sign of hemoglobinuria following a hemolytic transfusion reaction.
โ Febrile transfusion reaction โ๏ธ Incorrect
โค๏ธ Why this is incorrect
๐น Febrile reactions usually present with fever and chills only and do not cause flank pain, hypotension, or hemoglobinuria.
๐น Severe symptoms such as flank pain and hypotension strongly suggest a hemolytic reaction, not a febrile reaction.
โ Circulatory overload transfusion reaction (TACO) โ๏ธ Incorrect
โค๏ธ Why this is incorrect
๐น Circulatory overload presents with dyspnea, hypertension, crackles, pulmonary edema, and jugular vein distention.
๐น This client instead has hypotension and flank pain, findings that are inconsistent with TACO.
โ Allergic transfusion reaction โ๏ธ Incorrect
โค๏ธ Why this is incorrect
๐น Allergic reactions commonly produce urticaria, pruritus, flushing, wheezing, or angioedema.
๐น They do not typically cause flank pain, hypotension, or hemoglobinuria, making this diagnosis unlikely.
โ Plan to administer epinephrine โ๏ธ Incorrect
โค๏ธ Why this is incorrect
๐น Epinephrine is indicated for anaphylactic transfusion reactions, not for acute hemolytic reactions.
๐น Management of a hemolytic reaction focuses on stopping the transfusion, maintaining circulation, protecting kidney function, and notifying the blood bank.
โ Plan to administer non-chelating agent โ๏ธ Incorrect
โค๏ธ Why this is incorrect
๐น Chelating agents are used to treat heavy metal poisoning, not transfusion reactions.
๐น They have no role in managing acute hemolytic transfusion reactions.
โ Place adolescent in high-Fowler's position โ๏ธ Incorrect
โค๏ธ Why this is incorrect
๐น High-Fowler's position is appropriate for clients with respiratory distress or circulatory overload, not as a primary intervention for hemolytic transfusion reactions.
๐น The priority is to maintain circulation and monitor for shock and renal complications.
โ Blood calcium levels โ๏ธ Incorrect
โค๏ธ Why this is incorrect
๐น Calcium monitoring is not a priority indicator of improvement in an acute hemolytic transfusion reaction.
๐น The immediate concerns are shock, hemolysis, and kidney function.
โ Presence of jugular vein distention โ๏ธ Incorrect
โค๏ธ Why this is incorrect
๐น Jugular vein distention is associated with circulatory overload (TACO) rather than hemolytic transfusion reactions.
๐น This client shows signs of hypotension, not fluid overload.
โ Blood sodium levels โ๏ธ Incorrect
โค๏ธ Why this is incorrect
๐น Sodium levels are not significantly affected during an acute hemolytic transfusion reaction.
๐น Monitoring urine output, urine color, renal function, and signs of shock is much more clinically important.