Measure lactic acid level
🔴 Lactic acid helps determine the severity of tissue hypoperfusion in sepsis.
🔴 A high lactate level suggests cells are not receiving enough oxygen, even if the oxygen saturation appears acceptable.
🔴 This client has signs of sepsis, including fever, tachycardia, tachypnea, hypotension, altered mental status, and infection source.
🔴 Measuring lactate early helps guide the urgency of treatment and the need for aggressive fluid resuscitation.
🔴 Lactate should be rechecked if initially elevated to evaluate response to therapy.
Obtain blood cultures
🟠 Blood cultures should be obtained before antibiotics when possible.
🟠 This helps identify the organism causing sepsis and guides later antibiotic adjustment.
🟠 Cultures should not delay antibiotic therapy if the client is unstable.
🟠 This client has a likely infected diabetic foot wound with purulent drainage, making bloodstream infection a concern.
🟠 Early cultures improve targeted treatment after initial broad-spectrum coverage is started.
Obtain a sputum culture
🟡 A sputum culture helps identify a respiratory source of infection.
🟡 This client has crackles in the lung bases, tachypnea, and oxygen saturation of 93% on oxygen.
🟡 These findings may suggest possible respiratory involvement or pneumonia contributing to sepsis.
🟡 Culturing suspected infection sources supports accurate diagnosis and antimicrobial narrowing.
🟡 Source identification is a key part of early sepsis management.
Rapidly administer bolus of normal saline
🟢 Rapid IV fluid administration helps restore intravascular volume and tissue perfusion.
🟢 This client has hypotension at 98/60 mm Hg, tachycardia, dry mucous membranes, and sepsis risk.
🟢 Sepsis causes vasodilation and capillary leakage, which can reduce effective circulating volume.
🟢 A bolus of isotonic crystalloid, such as normal saline, helps support blood pressure and organ perfusion.
🟢 Early fluids help reduce progression to septic shock.
Obtain a UA
🔵 A urinalysis helps assess for a urinary source of infection.
🔵 Older adults with infection can present with altered mental status rather than classic urinary symptoms.
🔵 Diabetes increases the risk for urinary tract infection and complicated infection.
🔵 Identifying all possible infection sources is important in sepsis management.
🔵 UA results can guide further testing, culture decisions, and antimicrobial therapy.
Administer broad-spectrum antibiotics
🟣 Broad-spectrum antibiotics are a priority in the first hour of sepsis treatment.
🟣 Early antibiotic therapy reduces bacterial load and helps prevent worsening organ dysfunction.
🟣 The client has a likely infection source from the purulent diabetic foot wound and systemic signs of sepsis.
🟣 Antibiotics should ideally be given after cultures are obtained, but treatment should not be significantly delayed.
🟣 Timely antibiotics are essential to prevent progression to septic shock.
Type and cross-match for 2 units of packed RBCs
⚫ This client’s hemoglobin is 15 g/dL and hematocrit is 45%, which do not indicate acute blood loss or need for transfusion.
⚫ Type and cross-match is not part of the immediate first-hour sepsis priority unless bleeding or severe anemia is present.
Insert a nasogastric tube
⚫ An NG tube is not a first-hour sepsis intervention for this client.
⚫ It may be used for bowel obstruction, gastric decompression, or severe vomiting, but it does not treat sepsis or prevent septic shock.