End
1 :

Hint : ๐Ÿ”น Long-term PPIs weaken bones

Correct Answers:

  • Omeprazole


Rationale :

๐Ÿ”น Omeprazole is a proton pump inhibitor (PPI) used long-term for peptic ulcer disease

๐Ÿ”น Chronic PPI use reduces calcium absorption by decreasing gastric acid

๐Ÿ”น Reduced calcium absorption leads to decreased bone mineral density

๐Ÿ”น Long-term therapy is associated with an increased risk of osteoporosis and fractures

๐Ÿ”น This adverse effect is most significant with prolonged use

Famotidine

๐Ÿ”น Famotidine is an H2 receptor antagonist

๐Ÿ”น It has a much lower risk of bone density loss compared to PPIs

Bismuth

๐Ÿ”น Bismuth is used for H. pylori treatment and gastric protection

๐Ÿ”น It is not associated with bone metabolism changes

Magnesium hydroxide

๐Ÿ”น Magnesium hydroxide is an antacid/laxative

๐Ÿ”น It does not cause osteoporosis and may actually supply magnesium


Distractor Analysis :

Rationale for Incorrect Options to be Available Soon

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