End
1 :

Hint : ๐Ÿ’‰ Think โ€œno intrinsic factor, no Bโ‚โ‚‚ absorption.โ€

Correct Answers:

  • Pernicious anemia


Rationale :

๐Ÿ’Ž Pernicious anemia is a type of vitamin Bโ‚โ‚‚ deficiency anemia that occurs when the body lacks intrinsic factor, a glycoprotein secreted by the gastric parietal cells.

๐Ÿ’Ž Without intrinsic factor, vitamin Bโ‚โ‚‚ cannot be absorbed in the ileum, leading to impaired red blood cell (RBC) production and resulting in megaloblastic anemia.

๐Ÿ’Ž Symptoms include fatigue, pallor, glossitis (smooth, red tongue), and neurological manifestations such as numbness, tingling, and balance disturbances due to demyelination.

๐Ÿ’Ž Treatment involves lifelong vitamin Bโ‚โ‚‚ replacement, usually through intramuscular injections, since oral supplementation is ineffective without intrinsic factor.


Distractor Analysis :

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