End
1 :

Hint : 🦶Prevention—not for flares.

Correct Answers:

  • "Allopurinol is used only for the prevention of gout attacks."


Rationale :

💊Allopurinol lowers serum uric acid by inhibiting xanthine oxidase, making it a prophylactic agent to prevent future flares rather than treat an acute gout attack.

💊During an acute flare, pain and inflammation are best managed with NSAIDs, colchicine, or corticosteroids, not urate-lowering therapy initiation.

💊Starting or adjusting allopurinol during a flare can destabilize urate pools and is associated with worsening/prolongation of acute symptoms.

💊Allopurinol is typically initiated after the acute episode resolves, often with anti-inflammatory prophylaxis (e.g., low-dose colchicine) to prevent flare precipitation.

💊Key teaching is that allopurinol provides long-term control of hyperuricemia and reduces tophi formation, but it does not relieve acute pain.


Distractor Analysis :

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